The Mini Guide to Vertical AI

Learn to spot opportunities

Greg Isenberg

Oct 10, 2024

Let’s talk about a space that could outgrow SaaS: vertical AI.

Vertical AI is software built for a specific industry’s quirks. Think healthcare, insurance, construction—each has its own workflows, rules, and pain points.

These quirks aren’t problems—they’re opportunities. Solve them, and businesses will pay big.

Imagine an AI that doesn’t just help an insurance agent but becomes the agent—underwriting policies, handling claims, spotting fraud. If you ran that business, you’d pay a fortune for it.

early days in vertical ai

The rise of vertical software has been wild. A16z breaks it down into 3 waves and it really clicked for me when they said it like this:

First wave, cloud brought services online (commerce with Shopify, service backoffice with ServiceTitan etc).

Second wave added fintech to cloud. This supercharged revenue (Toast hit $1.5B ARR, 80% from financial services).

Now, we're entering the third wave, cloud + fintech + AI. This is turning labor into software.

the waves of vertical saas

So, I put together a quick guide to help you spot vertical AI startup opportunities.

Data goldmines 

Look for industries drowning in unstructured data. Think doctor's notes, legal documents, or sensor data from factories. The messier and more proprietary, the better.

High-stakes decisions

Find areas where mistakes cost millions. Insurance underwriting, drug discovery, or supply chain management. AI that reduces errors here is invaluable.

Time-sucking tasks

Identify workflows where highly paid professionals spend hours on repetitive work. Legal discovery, financial audits, or medical diagnoses are prime targets.

Regulatory mazes

Sectors with complex, ever-changing regulations are ripe for AI. Think finance, healthcare, or environmental compliance.

Industry jargon

Fields with their own jargon and context are perfect. The more specialized, the harder it is for general AI to compete.

Fragmented industries

Sectors full of small players—construction, agriculture, local government—are gold mines lacking cutting-edge tech.

Data network effects

Look for places where more usage is better data, creating a flywheel.

Human-AI teamwork

Areas where AI can augment rather than replace humans entirely. I noticed this often leads to faster adoption which is obviously something we'd love.

If you tick a lot of these boxes, pretty sure you might be onto something big.

loved this graphic by matt which shows a bunch of vertical AI ideas by

loved this graphic by matt which shows a bunch of vertical AI ideas by

I hope this got your creative juices flowing.

What’s cool is the next wave of tech success stories won't all come from Stanford dorms. They'll emerge from law firms, hospital wards, and factory floors. Trapped in those people's brains is some insights that could lead to the next big vertical AI agent.

The vertical AI boom is just starting. The opportunity is massive, and the least competitive, most niche vertical ai software ones are the ones to look out for.

Time to start digging.


Note: I write posts like this every week, packed with free startup ideas, insights on business building, and strategies for succeeding in the online world. It’s called Greg’s letter.

Join over 100,000 people and have it delivered straight to your inbox.

Want more insights, faster, straight to your inbox?

2122+

Free ideas given since 2020.

Join 125,000+ to get your creative juices flowing

Want more insights, faster, straight to your inbox?

2122+

Free ideas given since 2020.

Join 125,000+ to get your creative juices flowing

Want more insights, faster, straight to your inbox?

2122+

Free ideas given since 2020.

Want more insights, faster, straight to your inbox?

2122+

Free ideas given since 2020.

Join 125,000+ to get your creative juices flowing

Find and follow me over here

©gregisenberg 2025